Autoantibodies in human anti-Ro sera specifically recognize deproteinized hY5 Ro RNA
نویسندگان
چکیده
منابع مشابه
Human Anti-p68 Autoantibodies Recognize
Autoimmune phenomenaare known to occur in a large variety of human diseases (for review see reference 1) . Antibodies to self-components (autoantibodies) can be directed against organ-specific or non-organ-specific target structures and can develop transiently or persist chronically. Some are regarded as diagnostic markers for certain diseases, and some are pathogenic or contribute to disease d...
متن کاملBiochemical and immunological heterogeneity of the Ro ribonucleoprotein particles. Analysis with sera specific for the RohY5 particle.
Anti-Ro autoantibodies found in sera from patients with systemic lupus erythematosus and related diseases precipitate four RNAs (hY1-hY5) from human cell extracts. We identified two patient sera that selectively immunoprecipitated from such extracts the Ro particle containing the hY5 RNA (RohY5 particle). Using cell fractions either enriched in or depleted of RohY5 particles, we have shown that...
متن کاملA shared idiotype among human anti-Ro/SSA autoantibodies [published erratum appears in J Exp Med 1990 Feb 1;171(2):591]
Idiotypes and antiidiotypes are thought to be important immune regulators and have provided clues for the origin and pathogenicity of autoantibodies. Many lupus and Sjögren's syndrome patients, as well as most neonatal lupus infants with congenital heart block or dermatitis, have antibodies to the ribonucleoprotein Ro/SSA, which is one of a group of RNA-protein autoantigens commonly found in hu...
متن کاملHuman Ro ribonucleoprotein particles: characterization of native structure and stable association with the La polypeptide.
Anti-Ro autoantibodies, found in sera of patients with systemic lupus erythematosus, Sjogren's syndrome, and related diseases, target the Ro ribonucleoprotein particles (RNPs). Although the polypeptide and RNA components of the Ro RNPs have been characterized, much less is known about the native structure of these particles. We have now characterized by biochemical techniques intact Ro ribonucl...
متن کاملAnti-Ro/SSA autoantibodies over time in mothers of children with congenital complete heart block.
Sir, It is commonly assumed that the titer of antiRo/SSA antibodies remains stable over the years, but data in the literature are scanty (14). Congenital heart block (CHB) is a multidisciplinary field; although anti-Ro/SSA antibodies appear to be pathogenically linked to it (5-7), the cardiological literature often describes CHB mothers presumed to be antiRo/SSA negative (8). The aim of this st...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2008
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.1995.tb03468.x